Lysine-based polycation:heparin coacervate for controlled protein delivery
نویسندگان
چکیده
منابع مشابه
Controlled mixing of lanthanide(III) ions in coacervate core micelles.
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Polyethylenimine (PEI), one of the most frequently used polycations for non-viral nucleic acid delivery, exhibits good transfection efficiency to cultured cells but generally has to be used in restricted concentration ranges due to high cytotoxicity. We recently reported a family of HPMA-co-oligolysine brush copolymers that show nucleic acid delivery efficiencies approaching that of PEI. Guanid...
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Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses an...
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BACKGROUND The purpose of this study was to develop a mucoadhesive coacervate microparticulate system to deliver viable Lactobacillus rhamnosus cells into the gut for an extended period of time while maintaining high numbers of viable cells within the formulation throughout its shelf-life and during gastrointestinal transit. METHODS Core coacervate mucoadhesive microparticles of L. rhamnosus ...
متن کاملProtein-Based Drug-Delivery Materials
There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these bi...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2014
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2013.09.012